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Cyclin-dependent kinases (CDKs), play essential roles in cell cycle progression. CDK activity is controlled through phosphorylation and inhibition by CDK inhibitors, such as p16. Mutations in p16 can lead to diseases such as cancer. This study examines a series of p16 mutants and their molecular interactions with CDK4 using modelling, molecular dynamics simulations, and docking studies. Despite no significant structural changes in p16 due to mutation, the binding affinity was found to be affe...
Software methodologies to develop autonomic computing systems are not mature. As far as we know, there are no studies on composition of design patterns and pattern languages for autonomic computing domain. Static approach to configure services yields inflexible, often inefficient, applications and software architectures. Complex service request involving multiple tasks (operations) may fail due to unavailability of suitable Web services advertised in the registry. In this paper, we propose so...
A novel ring transformation reaction for the synthesis of 3-(3-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-2H-chromen-2-ones has been described. Reaction of 3-(2-bromoacetyl)coumarins (1) with 5-aryl-1,3,4-oxadiazole-2-thiol (2) gave ketones (4a–h). The in situ formed ketones (4a–h) were reacted with hydrazine hydrate to give 3-(3-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-2H-chromen-2-ones (3a–h) and not 5 or 6. The compounds (3a–h) can also be prepared by the reaction o...
Recently, many data embedding schemes using the quantized DCT coefficients have been proposed for achieving the robustness. However, most of the schemes lack to strike a trade off between the embedding capacity and the visual quality. Achieving more embedding capacity by maintaining the visual quality has become a challenging task. Most of the DCT based data embedding schemes result in various visual distortions for not considering the HVS characteristics while embedding. The widely used visu...
Current autonomic computing systems are ad hoc solutions that are designed and implemented from the scratch, and there are no universal standard (or well established) software methodologies to develop. There are also significant limitations to the way in which these systems are validated. When designing software, in most cases two or more patterns are to be composed to solve a bigger problem. A composite design patterns shows a synergy that makes the composition more than just the sum of its ...
In this paper, we present a numerical integration method to solve singularly perturbed delay differential equations. In this method, we first convert the second order singularly perturbed delay differential equation to first order neutral type delay differential equation and employ the numerical integration. Then, linear interpolation is used to get three term recurrence relation which is solved easily by discrete invariant imbedding algorithm. The method is demonstrated by implementing ...
The multilineage potentiality of cord blood stem cells has been experimentally proven in a number of cell based therapies. Umbilical cord blood (UCB) derived mesenchymal stem cells (MSCs), on prolonged exposure with Lascorbic acid have been successfully differentiated in to osteoblasts (bone forming cells) without altering the phenotype of the cells. In this case study, the role of L-ascorbic acid on collagen biosynthesis and mineral deposition in MSCs has been assessed, which are ultimately ...
The reversible data embedding is emerging due to its various watermarking and steganography applications. Most of the reversible data embedding schemes result in visual distortions while embedding the data into DCT domain. In this paper we propose a reversible data embedding scheme for MPEG-4 video which embed the data into middle frequency coefficients of quantized DCT blocks and use HVS based visual quality metrics. The relative improvement in the visual quality and capacity is compared and...
Ro-Boat is an autonomous river cleaning intelligent robot incorporating mechanical design and computer vision algorithm to achieve autonomous river cleaning and provide a sustainable environment. Ro-boat is designed in a modular fashion with design details such as mechanical structural design, hydrodynamic design and vibrational analysis. It is incorporated with a stable mechanical system with air and water propulsion, robotic arms and solar energy source and it is proceed to become ...
A numerical study of the flow between two coaxial cylinders, where one of the cylinders has a step change in radius, is carried out. The inner cylinder rotates and the outer cylinder is stationary. Computation is restricted to axisymmetric motion since instability in flow between coaxial cylinders is found to first occur in the form of axisymmetric Taylor vortices. In the presence of a step, Taylor vortices are found to appear first in the region where the gap between the cylinders is l...
Diesel engines generate undesirable emissions during the combustion process. Various control methods have been developed to reduce nitrogen oxides (NOx) and particulate matter (PM) emissions from diesel engines so that the strict emission regulations can be fulfilled. Oxides of nitrogen (NOx) and particulate matter (PM) are the main pollutants from diesel engines and it has been proven that the method of introducing water with fuel to be a powerful and economical technique for reducing t...
An efficient and eco‐friendly method has been developed for the synthesis of selenadiazolo benzimidazoles by the condensation of N‐benzylbenzo[c][1,2,5]selenadiazole‐4,5‐diamine with various aromatic aldehydes catalyzed by xanthan sulfuric acid. All the synthesized compounds 5a–j were evaluated for in vitro antibacterial activity against Gram‐positive bacterial strains (Bacillus subtilis, Staphylococcus aureus, and Streptococcus pyogenes), and Gram‐negative bacterial strains (Escherichia ...
A rapid, specific, and reliable isocratic LC–MS/MS method has been developed and validated for the identification and characterization of the stressed degradation products of Entecavir (ETV). ETV, an antiviral drug, was subjected to hydrolysis (acidic, alkaline, and neutral), oxidation, photolysis and thermal stress, as per the international conference on harmonization specified conditions. The drug showed extensive degradation under oxidative and acid hydrolysis stress conditions. Howev...
During the last century, natural fibers and particulates are used as reinforcement in polymer composite that has been continuously growing in the composite industry. This polymermatrix composite haswide range of applications in hostile environmentwhere they are exposed to external attacks such as solid particle erosion. Also, the mechanical properties of different polymer composites show the best alternate to replace the metal material. In the present investigation, an attempt has been mad...
The broad objective of this paper is to study the surface of the corroded metals by using proximity sensor which works on the principle of light scattering by objects. The present work discussed a simple low cost sensor design making use of plastic optical fiber. The sensor used is insensitive to source fluctuation and can detect surface roughness of the metals. The average surface roughness of the samples in different concentrations of acidic medium has been studied using the sensor. The...
Not attached.
Glasses with composition xNa2O-(40-x)Bi2O3-20CdO-40B2O3 where (0 ≤ x ≤ 40) have been prepared using melt quench technique. Optical absorption spectra of the pure glasses reveled that the cutoff wave length decreases and optical band gap (Eopt) increases where as Urbach energy (ΔΕ) decreases with increase in Na2O content. The Eopt values of these glasses are found to be in the range 2.818-3.217 eV where as the values of ΔΕ are in the range 0.23-0.35 eV.
The influence of SiO2 capping and excitation wavelength on photoluminescence (PL) of ZnO nanoparticles was studied. XRD and FE-SEM analysis of the samples showed that the particles size reduced from 54 nm to 10 nm with SiO2 capping. The PL spectra of ZnO-SiO2 nanocomposites were acquired with 320 and 353 nm excitation wavelengths. A sharp UV emission positioned at 398 nm was obtained with 353 nm excitation wavelength and its intensity is five times greater than the one achieved with 320 n...
The osteogenic potential of mesenchymal stem cells (MSCs) from umbilical cord blood (UCB) on porous poly lactide-co-glycolide (PLGA) scaffolds have been reported to differentially support osteogenic differentiation based on polymer composition (80:20, 75:25 and 70:30 percent of PLA: PGA, respectively). Along with polymer composition; fused NaCl crystal matrix prior to solvent casting improves the porosity and pore interconnectivity in 3D scaffolds, which has significant impact on cell pro...
To facilitate business growth assessment of customer's, satisfaction and loyalty levels in mobile sector are two important issues which need in-depth investigation. These two levels of customers are non linearly related to their corresponding attributes. The past studies have mostly assumed linear relation and have mostly used regression based models for estimation of these levels and the results are not encouraging. To overcome this limitation, the present study has developed simple non li...
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