Anti-hyperglycemic, pathogenic and anticancer activities of Bambusa arundinacea mediated Zinc Oxide nanoparticles

Abstract

Diabetes can be treated effectively by the nanoparticles (NPs), which have been converted into nanomedicine. The present study describes the synthesis of Zinc oxide nanoparticles (ZnO NPs) using Bambusa arundinacea (BA), their antidiabetic, antibacterial, and anticancer potential. Histopathological studies of synthesized ZnO NPs and BA extract were carried out on male Wistar rats. The Wistar rats were divided into normal, toxicant, standard, and test groups. It is observed that the ZnO NPs have shown enhanced anti-diabetic potential when compared with BA extract. It is mainly due to the extensive pharmacological and biological properties of ZnO NPs. Further experiments needed to be carried out to confirm the exact mechanism of ZnO NPs for anti-hyperglycemic activity. Good antibacterial efficacy of biosynthesized ZnO NPs against gram-positive organisms was observed. The zone of inhibition values of 14, 16, 17, 19 mm for Staphylococcus aureus (S.aureus) and 12, 14, 15, 17 mm for Bacillus subtilis (B. Substilis) were observed for the concentration of 25, 50, 100, 150 μl. Further, ZnO NPs also exhibited anticancer activity against MCF-7 cell lines. These results indicate that bio-synthesized ZnO NPs have prospective pharmaceutical applications.