Please use this identifier to cite or link to this item:
http://localhost:8080/xmlui/handle/123456789/3418| Title: | Syntheses of Human TLR8Specific SmallMolecule Agonists |
| Authors: | Beesu, Mallesh Kokatla, Hari Prasad David, Sunil A. |
| Issue Date: | 2016 |
| Publisher: | Syntheses of Human TLR8Specific SmallMolecule Agonists Springer |
| Abstract: | Human tolllike receptor (hTLR)8 is expressed in myeloid dendritic cells, monocytes, and monocytederived dendritic cells. Engagement by TLR8 agonists evokes a distinct cytokine profile which favors the development of type 1 helper T cells. Focused exploration of structureactivity relationships in the imidazoquinolines has led to the identification of several novel human TLR8specific agonists. The synthetic procedures for bestinclass analogues encompassing four chemotypes are described. |
| Description: | NITW |
| URI: | http://localhost:8080/xmlui/handle/123456789/3418 |
| Appears in Collections: | Chemistry |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Book_Syntheses of Human TLR8-Specific Small-Molecule Agonists - Springer.pdf | 250.1 kB | Adobe PDF | View/Open |
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