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http://localhost:8080/xmlui/handle/123456789/3044| Title: | One-pot synthesis of trisubstituted pyrazoles via multicomponent approach |
| Authors: | Santhosh, P. Chunduru, V.S.R Rajeswar Rao, V. |
| Keywords: | Catalysts Ethanol |
| Issue Date: | 2011 |
| Publisher: | Khimiya Geterotsiklicheskikh Soedinenii |
| Abstract: | A regioselective enzyme-catalyzed system is selected for the synthesis of 1,3,5-trisubstituted pyrazole derivatives by adding phenyl hydrazines, nitroolefins, and benzaldehydes. The reaction is performed in a one-pot vessel with a yield ranging from 49 to 90%. TLL@MMI, immobilized Thermomyces lanuginosus lipase (TLL) on a multivariate of MOF-5/IRMOF-3 (MMI), showed good performance for the catalysis of this reaction. The prepared biocatalyst was characterized by FTIR, XRD, SEM, and EDX. The thermal and solvent stability of TLL@MMI was investigated in MeOH and EtOH after 24 h incubation. In the presence of 100% concentrations of EtOH, TLL@MMI has 80% activity |
| Description: | NITW |
| URI: | http://localhost:8080/xmlui/handle/123456789/3044 |
| Appears in Collections: | Chemistry |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| rangraz-et-al-2024-one-pot-synthesis-of-1-3-5-trisubstitued-pyrazoles-via-immobilized-thermomyces-lanuginosus-lipase.pdf | 5.11 MB | Adobe PDF | View/Open |
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