Design, Synthesis and Evaluation of Novel Benzoxazole, Benzimidazole and Benzthiazole Based Cationic Lipids as Anticancer agents.

Abstract

Herein, we report on the design, synthesis and cytotoxicities of a series of novel benzoxazole, benzimidazole and benzthiazole based cationic lipids (1a-12b) in breast and lung cancer cell lines. The in vitro cytotoxicities of these lipids were evaluated using MTT assay. The results of the present structure-activity investigation convincingly demonstrate that the benzthiazole based lipids with protonated ammonium group in its headgroup region and C14 hydrocarbon chain as anchoring group showed highest anticancer activity among the series of benzoxazole, benzimidazole and benzthiazole based lipids studied presently. The results indicated that the designed systems are quite capable as anti cancer agents.