Multi-component synthesis of 3-{3-[2-(1H-Indol-3-yl)ethyl]}-2,3-dihydro-2- (aryliminothiazol-4-yl)-2H-chromen-2-ones

Abstract

Tryptamines are biologically active monoamine alkaloids whose structural motif is embedded in numerous natural products and commercial drugsCitation 1 , Citation2 and are involved in various biological processes.Citation 3 Tryptamine (3) acts as a serotonin releasing agentCitation 4 and a serotonergic activity enhancer.Citation 5 It is also a biosynthetic precursor of many alkaloid natural productsCitation 6 and is often used as a chemical building block in the total synthesis of biologically active and pharmaceutically important compounds.Citation 7 , Citation8 Coumarins (2H-1-benzopyran-2-ones, 1) are important oxygen containing heterocycles, commonly present in several natural products,Citation 9,10 and exhibit a broad range of biological and pharmacological activitiesCitation 11 , Citation12 and have various technological applications.Citation 13 Several synthetic analogs of coumarins such as novobiocin, chlorobiocin, coumermycin, simocyclinone, demiflin, and flavaxate have been developed into useful drugs