One-pot synthesis of fused 3,4-dihydropyrimidin-2(1H)-ones and thiones using a novel ionic liquid as an efficient and reusable catalyst: improved protocol conditions for the Biginelli-like scaffolds

Abstract

A novel ionic liquid with multi-SO 3 H groups has been found to be an effi cient acid catalyst for the one-pot three-compo-nent synthesis of fused 3,4-dihydropyrimidin-2(1 H )-ones and thiones under solvent free conditions. Good yields, short reac-tion times, straight forward workup, reusability of the catalyst and green conditions are the most obvious advantages of this methodology.