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http://localhost:8080/xmlui/handle/123456789/2368| Title: | New, Convenient, One-Pot Method for the Synthesis of Thiazolyl-pyrazolones from Dehydroacetic Acid Derivative via a Multicomponent Approach |
| Authors: | Penta, S. ; Vedula R.R., R.R. |
| Keywords: | : Aromatic primary amine 3-(2-bromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one multicomponent thiosemicarbazide |
| Issue Date: | 2012 |
| Publisher: | An International Journal for Rapid Communication of Synthetic Organic Chemistry |
| Citation: | 10.1080/00397911.2011.558969 |
| Abstract: | A convenient one-pot method for the synthesis of thiazolyl-pyrazolones was described in excellent yields. Reaction of 3-(2-bromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one with thiosemicarbazide and ethyl 2-(2-arylhydrazono)-3-oxobutanoates in anhydrous ethanol under reflux conditions afforded the corresponding 4-(2-arylhydrazono)-1-(4-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)thiazol-2-yl)-3-methyl-1H-pyrazol-5(4H)-one in good yields. The structures of newly synthesized compounds were established on the basis of elemental analysis, infrared, 1H NMR, and mass spectroscopic studies |
| Description: | NITW |
| URI: | http://localhost:8080/xmlui/handle/123456789/2368 |
| Appears in Collections: | Chemistry |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| New Convenient One-Pot Method for the Synthesis of Thiazolyl-pyrazolones from Dehydroacetic Acid Derivative via a Multicomponent Approach.pdf | 381.01 kB | Adobe PDF | View/Open |
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