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http://localhost:8080/xmlui/handle/123456789/2232| Title: | A FACILE ONE-STEP MULTI-COMPONENT APPROACHTOWARD THE SYNTHESIS OF3-(2-AMINO-4-THIAZOLYL)COUMARINS BY USINGTRIMETHYLSILYL ISOTHIOCYANATE AND THEIRANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY |
| Authors: | Ramagiri, Raj Kumar Vedula, Rajeswar Rao Thupurani, Murali Krishna |
| Keywords: | Coumarin Multi-component reaction |
| Issue Date: | 2015 |
| Publisher: | Phosphorus, Sulfur and Silicon and the Related Elements |
| Citation: | 10.1080/10426507.2014.990016 |
| Abstract: | A multi-component synthesis of 3-(2-amino-4-thiazolyl)coumarins has been re-ported from 3-(2-bromoacetyl)-2H-chromen-2-ones primary amines and using commerciallyavailable trimethylsilyl isothiocyanate. The structures of newly synthesized compounds werecharacterized by their analytical and spectral data. All the title compounds were screenedfor antioxidant and anti-inflammatory activity. Among the screened compounds, 4b exhibitedhighest free radical scavenging activity and also 4b was found to be effective in inhibiting theprotein denaturation at all tested concentrations. |
| Description: | NITW |
| URI: | http://localhost:8080/xmlui/handle/123456789/2232 |
| Appears in Collections: | Chemistry |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| A Facile One-Step Multi-Component Approach toward the Synthesis of 3- 2-Amino-4-Thiazolyl Coumarins by using Trimethylsilyl Isothiocyanate and their A.pdf | 457.57 kB | Adobe PDF | View/Open |
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