Synthesis of Aryl and Heteryl 1,3,4-Thiadiazinyl-phthalazine-1,4-dione Derivatives via a Multicomponent Approach

Abstract

An expeditious one-pot method has been developed for the synthesis of aryl, heteryl thiadiazinyl-phthalazine-1,4-diones via a multicomponent approach. Reaction of phenacyl bromides with thiocarbohydrazide and phthalic anhydride afforded corresponding aryl thiadiazinyl-phthalazine-1,4-diones. Similarly, reaction of 3-(2-bromoacetyl)coumarins with thiocarbohydrazide and phthalic anhydride afforded required heteryl thiadiazinyl-phthalazine-1,4-diones under the same reaction conditions in excellent yields. The structure of all the synthesized compounds was confirmed from their analytical and spectral data.