NOVEL, SIMPLE, AND EFFICIENT SYNTHESIS OF 3-(2-(5-(BENZYLIDENEAMINO)-3-PHENYL-1H-PYRAZOL-1-YL)THIAZOL-4-YL)-4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE DERIVATIVES VIA A ONE-POT,FOUR-COMPONENT CONDENSATION REACTION

Abstract

The synthesis of 3-(2-(5-(benzylideneamino)-3-phenyl-1H-pyrazol-1-yl)thiazol-4-yl)-4-hydroxy-6-methyl-2H-pyran-2-one derivatives was achieved through a one-pot,four-component reaction involving condensation of 3-(2-bromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one, thiosemicarbazide, phenacylcyanaide, and various aryl aldehydesin dry alcohol and few drops of acetic acid under reflux condition. This four-componentreaction has some advantages such as ease of handling, good yields, and easy workup. Allstructures of newly prepared compounds were confirmed by analytical and spectral data.