A facile synthesis of some new 3-(2-hydroxy-4-thiazolyl) coumarins and their derivatives

Abstract

t: Treatment of 3-(2-bromoacetyl)coumarins with potassium thiocyanate provides 3-(2-thiocyanatoacetyl)coumarins which on treatment with methanolic.HCI gives 3-(2-hydroxy-4-thiazolyI)-2H-lbenzopyran-2-ones (2) but not oxathiole derivative (4a) or 3-(2-chloro-4-thiazolyl)coumarins (4b). 2 undergoes smooth condensation with alkyl, aralkyl halides to give corresponding ethers. The structure of newly synthesized compounds were established on the basis of spectral data (1R, Ρ MR and MS).