Synthesis of 3-( l-aryl-2-mercaptoimidazolyl)- 2H-l-benzopyran-2-one derivatives

Abstract

Reaction of 3-(2-bromoacetyl) coumarins with various substituted aromatic primary amines resulted in the formation of 3-(2- anilino acetyl) coumarins 1 which on subsequent reaction with potassium thiocyanate furnishes corresponding 3-(1 -aryl-2- mercapto-imidazolyl)-2H-l -benzopyran-2-ones 2. The latter on treatment with alkyl halides/phenacyl halides/acyl halides in the presence of anhydrous ethanol and DMF gave the corresponding thioethers and thioesters 3.