SYNTHESIS OF NEW ARYL IMIDAZOLE QUINOLINE-2-ONES

Abstract

A series of some new aryl imidazole quinoline-2-ones have been synthesized by condensing N-[- (Z)-l-(Hydrazino carbonyl)-2-Phenyl vinyl]acetamide with simple and substituted coumarins in acetic acid by two step process (method-Α) and one pot process (method-B). A comparative study of method-Α and method-B is briefly discussed. The compounds 4g showed maiked activity against S. aureus bacteria and the compounds 4f, 4h showed marked activity against E.Coli bacteria. The other compounds were moderately or weakly active against S. aureus and E. Coli. The compounds 4h, 41 showed marked activity against A. niger and the compounds 41 showed marked activity against C. albicans. The remaining compounds were moderately or weakly active against/!, niger and C. albicans.