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http://localhost:8080/xmlui/handle/123456789/1352| Title: | Antifertility agents—synthesis and activity |
| Authors: | Rajitha, B. Geetanjali, Y. Rao, M.K. Somayajulu, V.V. Atal, C.K. |
| Keywords: | Antifertility agents synthesis |
| Issue Date: | 1981 |
| Publisher: | Proceedings of the Indian Academy of Sciences - Chemical Sciences |
| Citation: | 10.1007/BF02879402 |
| Abstract: | Basic ethers, 2-phenyl-3-(p-β-dialkylaminoalkoxy)-phenyl 7(H) oxo furanocoumarin(VIa) and 9-methyl analog 2-phenyl-3-(p-β-dialkylaminoalkoxy)-phenyl-9-methyl 7(H) oxo furanocoumarin (VIb) have been synthesised by condensing 2-phenyl-3-p-hydroxyphenyl 7(H) oxo furanocoumarin (Va) and its 9-methyl analog (Vb) with appropriate β-tertiary aminoalkyl halide in acetone-potassium carbonate. Va and Vb were obtained by demethylating the methyl ethers IVa and IVb respectively with pyridine hydrochloride. IVa and IVb themselves were formed from the alkali-induced cyclisation of the ketones IIIa and IIIb. Among the compounds tested for antifertility activity, the basic ethers 12*, 14*, and 18* were found to have marked anti-implantation properties. |
| Description: | NITW |
| URI: | http://localhost:8080/xmlui/handle/123456789/1352 |
| Appears in Collections: | Chemistry |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Antifertility agents-synthesis and activity.pdf | 267.15 kB | Adobe PDF | View/Open |
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