A FACILE ONE STEP SYNTHESISCOUMARINO] DIMETHYL METHINESOF [3-(2-HYDRAZINO-4-THIAZOLYL)AND SOME 3-SUBSTITUTED-7H-6-(6/8,6,8-SUBSTITUTED- 3-COUMARINO)-s-TRIAZOL0[3,4-b][1,3,4]THIADIAZIN

Abstract

Some [3-(2-hydrazino-4-thiazolyl)coumarino]dimethyl methine derivatives (111) have beenprepared by the condensation of 3-(2-bromoacetyl)-coumarin and thiosemicarbazide in ace-tone. These compounds formation was further confirmed by the condensation of acetone thi-osemicarbazone (I) and p-N,N-dimethyl amino benzaldehyde thiosemicarbazone (11) with3-(2-bromoacetyl)coumarin in anhydrous ethanol and dimethyl formamide in a two stepprocess. 3-Substituted-7H-6-(6 or 8 or 6.8-disubstituted 3-coumarino)-s-triazolo[3,4-b][ 1,3,4]thiadiazines (V) have also been prepared from simple condensation of appropriate4-amino-5-mercapto-l , 2,4-triazole with various 3-(2-bromoacetyl) coumarins in anhydrousethanol and dimethyl formamide.