http://localhost:8080/xmlui/handle/123456789/210 2026-04-26T08:06:16Z http://localhost:8080/xmlui/handle/123456789/3418 Title: Syntheses of Human TLR8Specific SmallMolecule Agonists Authors: Beesu, Mallesh; Kokatla, Hari Prasad; David, Sunil A. Abstract: Human tolllike receptor (hTLR)8 is expressed in myeloid dendritic cells, monocytes, and monocytederived dendritic cells. Engagement by TLR8 agonists evokes a distinct cytokine profile which favors the development of type 1 helper T cells. Focused exploration of structureactivity relationships in the imidazoquinolines has led to the identification of several novel human TLR8specific agonists. The synthetic procedures for bestinclass analogues encompassing four chemotypes are described. Description: NITW 2016-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/3416 Title: Rongalite induced metal-free C(sp2)–H functionalization of indoles: direct access to 3-(sulfonylmethyl) indoles Authors: Thunga, Sanjeeva; Singh, Neetika; Inapanuri, Madhu; Kokatla, Hari Prasad Abstract: A rongalite-induced C(sp2)–H functionalization reaction has been developed for the synthesis of 3-(phenylsulfonylmethyl) indole derivatives from indole and arylsulfonyl hydrazides. This regioselective C–H functionalization provides a wide range of C-3 sulfonylmethyl indoles with upto 90% yields. Here, rongalite functions as a C1 unit source and a single electron donor. The use of inexpensive rongalite (ca. $0.03 per 1 g), mild reaction conditions and gram-scale synthesis are some of the key features of this methodology. Description: NITW 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/3415 Title: Rongalite as a Methylene Surrogate: Synthesis of Heterodiarylmethanes via C(sp2)‑H Functionalization Authors: Thunga, Sanjeeva; Inapanuri, Madhu; Singh, Neetika; Kokatla, Hari Prasad Abstract: An efficient method for the synthesis of heterodiarylmethanes through the coupling of imidazo[1,2-a]pyridines and heteroarenes using indoles employing rongalite as a methylenating reagent has been developed. This regioselective C−H functionalization provides a wide range of heterodiarylmethanes of imidazo[1,2-a]pyridines and imidazo[2,1-b]thiazole. Here, rongalite plays a crucial role in generating a C1 unit in situ, which triggers the heterodiarylmethylation process. The use of inexpensive rongalite (ca. $0.03/1 g), mild reaction conditions, and gram-scale synthesis are some of the key features of this methodology. Description: NITW 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/3414 Title: One-Pot Aminomethylation of Heteroarenes by Rongalite as In Situ C1 Source Authors: Thunga, Sanjeeva; Singh, Neetika; Anugu, Naveenkumar; Kokatla, Hari Prasad Abstract: Rongalite-mediated one-pot aminomethylation of heteroarenes using secondary amines/anilines has been developed. This transition-metal-free and mild reaction offers an efficient way to synthesize aminomethylated heteroaromatic compounds with high yields and broad functional group tolerance. Here, Rongalite plays a key role in generating the C1 unit source in situ, which triggers the aminomethylation process. This approach provides a library of aminomethylated imidazo[1,2-a]pyridines and imidazo[2,1-b]- thiazoles. Description: NITW 2024-01-01T00:00:00Z