DSpace Collection:http://localhost:8080/xmlui/handle/123456789/2102026-04-26T08:06:16Z2026-04-26T08:06:16ZSyntheses of Human TLR8Specific SmallMolecule AgonistsBeesu, MalleshKokatla, Hari PrasadDavid, Sunil A.http://localhost:8080/xmlui/handle/123456789/34182025-10-23T07:27:42Z2016-01-01T00:00:00ZTitle: Syntheses of Human TLR8Specific SmallMolecule Agonists
Authors: Beesu, Mallesh; Kokatla, Hari Prasad; David, Sunil A.
Abstract: Human tolllike receptor (hTLR)8 is expressed in myeloid dendritic cells, monocytes, and monocytederived dendritic cells. Engagement by TLR8 agonists evokes a distinct cytokine profile which favors the development of type 1 helper T cells. Focused exploration of structureactivity relationships in the imidazoquinolines has led to the identification of several novel human TLR8specific
agonists. The synthetic procedures for bestinclass analogues encompassing four chemotypes are described.
Description: NITW2016-01-01T00:00:00ZRongalite induced metal-free C(sp2)–H functionalization of indoles: direct access to 3-(sulfonylmethyl) indolesThunga, SanjeevaSingh, NeetikaInapanuri, MadhuKokatla, Hari Prasadhttp://localhost:8080/xmlui/handle/123456789/34162025-10-23T06:08:28Z2024-01-01T00:00:00ZTitle: Rongalite induced metal-free C(sp2)–H functionalization of indoles: direct access to 3-(sulfonylmethyl) indoles
Authors: Thunga, Sanjeeva; Singh, Neetika; Inapanuri, Madhu; Kokatla, Hari Prasad
Abstract: A rongalite-induced C(sp2)–H functionalization reaction has been developed for the synthesis of 3-(phenylsulfonylmethyl) indole derivatives from indole and arylsulfonyl hydrazides. This regioselective C–H functionalization provides a wide range of C-3 sulfonylmethyl indoles with upto 90% yields. Here, rongalite functions as a C1 unit source and a single electron donor. The use of inexpensive rongalite (ca. $0.03 per
1 g), mild reaction conditions and gram-scale synthesis are some of the key features of this methodology.
Description: NITW2024-01-01T00:00:00ZRongalite as a Methylene Surrogate: Synthesis of Heterodiarylmethanes via C(sp2)‑H FunctionalizationThunga, SanjeevaInapanuri, MadhuSingh, NeetikaKokatla, Hari Prasadhttp://localhost:8080/xmlui/handle/123456789/34152025-10-23T06:05:25Z2024-01-01T00:00:00ZTitle: Rongalite as a Methylene Surrogate: Synthesis of Heterodiarylmethanes via C(sp2)‑H Functionalization
Authors: Thunga, Sanjeeva; Inapanuri, Madhu; Singh, Neetika; Kokatla, Hari Prasad
Abstract: An efficient method for the synthesis of heterodiarylmethanes
through the coupling of imidazo[1,2-a]pyridines
and heteroarenes using indoles employing rongalite as a
methylenating reagent has been developed. This regioselective
C−H functionalization provides a wide range of heterodiarylmethanes
of imidazo[1,2-a]pyridines and imidazo[2,1-b]thiazole.
Here, rongalite plays a crucial role in generating a C1 unit in situ,
which triggers the heterodiarylmethylation process. The use of
inexpensive rongalite (ca. $0.03/1 g), mild reaction conditions, and
gram-scale synthesis are some of the key features of this
methodology.
Description: NITW2024-01-01T00:00:00ZOne-Pot Aminomethylation of Heteroarenes by Rongalite as In Situ C1 SourceThunga, SanjeevaSingh, NeetikaAnugu, NaveenkumarKokatla, Hari Prasadhttp://localhost:8080/xmlui/handle/123456789/34142025-10-23T05:59:13Z2024-01-01T00:00:00ZTitle: One-Pot Aminomethylation of Heteroarenes by Rongalite as In Situ C1 Source
Authors: Thunga, Sanjeeva; Singh, Neetika; Anugu, Naveenkumar; Kokatla, Hari Prasad
Abstract: Rongalite-mediated one-pot aminomethylation of
heteroarenes using secondary amines/anilines has been developed.
This transition-metal-free and mild reaction offers an efficient way to
synthesize aminomethylated heteroaromatic compounds with high
yields and broad functional group tolerance. Here, Rongalite plays a
key role in generating the C1 unit source in situ, which triggers the
aminomethylation process. This approach provides a library of
aminomethylated imidazo[1,2-a]pyridines and imidazo[2,1-b]-
thiazoles.
Description: NITW2024-01-01T00:00:00Z